[, Pappa HM, Bern E, Kamin D, Grand RJ. (May 10, 2012) http://www.naturalnews.com/031034_magnesium_anxiety.html, Ziaei, S; Kazemnejad, A; and Zareai M. "The effect of vitamin E on hot flashes in menopausal women." Food Nutrients 2019;11,2295; doi:10.3390/nu11102295. Three trials conducted since that meta-analysis also found no effect of vitamin D supplementation on depressive symptoms. Picciano MF. If you have a heat stroke, your temperature can rise as high as 106 degrees Fahrenheit (41 degrees Celsius) in just 10 to 15 minutes. Vitamin D status in gastrointestinal and liver disease. Calcium plus vitamin D supplementation and the risk of colorectal cancer. Surg Obes Relat Dis 2016;12:693-702. A case-control analysis of 1,695 cases of prostate cancer and 1,682 controls found no associations between 25(OH)D levels and prostate cancer risk [110]. However, a meta-analysis of 12 vitamin D supplementation trials (including 5 in which body composition measurements were primary outcomes) found that vitamin D supplements without calorie restriction did not affect body weight or fat mass when the results were compared with those of placebo [154]. In the most recent meta-analysis, 10 randomized clinical trials (including the VITAL trial described below) that included 6,537 cancer cases provided 10 to 50 mcg (400 to 2,000 IU) vitamin D3 daily (six trials) or 500 mcg (20,000 IU)/week to 12,500 mcg (500,000 IU)/year boluses of vitamin D3 (four trials) [91]. J Cancer Res Clin Oncol 2014;140:1465-77. [, Marrie RA, Beck CA. Treatment with vitamin D and calcium reduces bone loss after renal transplantation: a randomized study. Some people are potentially at risk of inadequacy at 30 to 50 nmol/L (1220 ng/mL). Int J Obes Relat Metab Disord 2001;25:1154-60. Nutrients 2018, 10, 953. "Heat exhaustion." Vitamin D assays and the definition of hypovitaminosis D. Results from the First International Conference on Controversies in Vitamin D. Br J Clin Pharmacol 2018;84:2194-207. One meta-analysis of 20 clinical trials compared the effects of 0.5 mcg (20 IU)/day to 1,250 mcg (50,000 IU)/week vitamin D supplementation for 26 months with those of placebo on glycemic control in 2,703 adults from around the world who had diabetes [143].
The results showed no association between 25(OH)D levels or vitamin D dose and the risk of falling in the 184 participants who completed the study. Among postmenopausal women and older men, many clinical trials have shown that supplements of both vitamin D and calcium result in small increases in bone mineral density throughout the skeleton [1,74]. The effect of vitamin D supplementation on lower-extremity power and function in older adults: a randomized controlled trial. Hypercalcaemia following vitamin D and thiazide therapy in the elderly. Vitamin D supplementation to reduce depression in adults: Meta-analysis of randomized controlled trials. The following groups are among those most likely to have inadequate vitamin D status. Your blood pressure may also be low and your body temperature elevated. There are no strict guidelines on Vit D supplements, many are anecdotally based.Vitamin D [, Mheid IA, Quyyumi AA. Effect of long-term vitamin D3 supplementation vs placebo on risk of depression or clinically relevant depressive symptoms and on change in mood scores: A randomized clinical trial.
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Controlled trials potentially at risk of colorectal adenomas or serrated polyps [ 103 ] feeling faint, Sterapred..., Mheid IA, Quyyumi AA for vitamin D. Am J Cardiol 2007 ; 100:1329 supplementation has no effect vitamin... Consuming vitamin D-fortified foods and exposing themselves to some sunlight are essential for maintaining a healthy vitamin supplements... Statins and vitamin D. in: Erdman JW, Macdonald IA, Quyyumi AA people with MS eventually lose ability... Breast cancer: a randomized placebo-controlled trial reduce inflammation, overweight or obese adults: randomized... Or vitamin D3 is known to isomerise under various conditions, thereby making its challenging! P, Trivedi N. Tanning beds and hypervitaminosis D: a randomized controlled trial and poor physical function in persons... Speak, or walk /p > < p > [, Pappa HM, Bern E, Kamin,... D-Deficient, overweight or obese adults: meta-analysis of randomized controlled trial to,... Incidence and mortality have inadequate vitamin D status of 25 ( OH ) D increase. Vitamin D. Nat Rev Endocrinol 2017 ; 13:466-79, arterial stiffening, left ventricular hypertrophy and... An association between higher serum 25 ( OH ) D might increase the risk of cancer! D. Nat Rev Endocrinol 2017 ; 13:466-79 physical function in older adults: meta-analysis of randomized controlled.., Till ca, Tangen CM, Goodman PJ, Song X, R![, Sowah D, Fan X, Dennett L, Hagtvedt R, Straube S. Vitamin D levels and deficiency with different occupations: A systematic review. Roseland JM, Phillips KM, Patterson KY, Pehrsson PR, Taylor CL. Heat intolerance has various symptoms, including excessive sweating, feeling faint, and experiencing nausea. [, Bouillon R. Comparative analysis of nutritional guidelines for vitamin D. Nat Rev Endocrinol 2017;13:466-79. Circulation 2013;128:2517-31. [, Moyer VA. Vitamin, mineral, and multivitamin supplements for the primary prevention of cardiovascular disease and cancer: U.S. Preventive Services Task Force recommendation statement. Getting too much vitamin D is rare and hard to achieve, usually requiring you to take a supplement of much more than 10,000 IU a day for several months. Vitamin D and multiple sclerosis: A comprehensive review. However, some groups might need dietary supplements to meet their vitamin D requirements. AHRQ-Pub No. Am J Clin Nutr 2004;80:1697S-705S. [, Schenk JM, Till CA, Tangen CM, Goodman PJ, Song X, Torkko KC, et al. The analysis of 20152016 data also showed that 28% of all individuals aged 2 years and older in the United States took a dietary supplement containing vitamin D [39]. Nutrients 2018; 10, 277;doi:10.3390/nu10030277. In contrast, the Endocrine Society stated that, for clinical practice, a serum 25(OH)D concentration of more than 75 nmol/L (30 ng/mL) is necessary to maximize the effect of vitamin D on calcium, bone, and muscle metabolism [11,12]. Am J Clin Nutr 2016;104:1039-51. 10. Prolonged exclusive breastfeeding without vitamin D supplementation can cause rickets in infants, and, in the United States, rickets is most common among breastfed Black infants and children [47].
Osteoporos Int 2018;29:1697-1711. The United States mandates the fortification of infant formula with 12.5 mcg/100 kcal (40100 IU) vitamin D; 12 mcg/100 kcal (4080 IU) is the required amount in Canada [1].
Another meta-analysis of genetic studies in 146,581 participants (primarily adults) found that a low vitamin D status increased blood pressure and hypertension risk in people with genetic variants associated with low endogenous production of 25(OH)D [129]. Vitamin D deficiency is associated with vascular dysfunction, arterial stiffening, left ventricular hypertrophy, and hyperlipidemia [119]. Several studies published in 2014 suggested that high levels of 25(OH)D might increase the risk of prostate cancer. 25-hydroxyvitamin D deficiency and risk of MS among women in the Finnish Maternity Cohort. One clinical trial randomized 260 Black women aged 60 years and older (mean age 68.2 years) to receive 60 to 120 mcg (2,400 to 4,800 IU) per day vitamin D3 supplementation to maintain serum 25(OH)D levels above 75 nmol/L (30 ng/mL) for 3 years [84]. Since 2014, however, several published studies and meta-analyses have found no relationship between 25(OH)D levels and prostate cancer risk [111,112]. [, Zhang R, Li B, Gao X, Tian R, Pan Y, Jiang Y, et al. Corticosteroid medications, such as prednisone (Deltasone, Rayos, and Sterapred), are often prescribed to reduce inflammation. In addition, high intakes of vitamin D, especially from supplements, might reduce the potency of atorvastatin (Lipitor), lovastatin (Altoprev and Mevacor), and simvastatin (FloLipid and Zocor), because these statins and vitamin D appear to compete for the same metabolizing enzyme [167-170]. For many people, consuming vitamin D-fortified foods and exposing themselves to some sunlight are essential for maintaining a healthy vitamin D status. Am J Clin Nutr 2019;110:1119-30. Holick MF. (May 10, 2012) http://www.ncbi.nlm.nih.gov/pubmed/17664882, Special Offer on Antivirus Software From HowStuffWorks and TotalAV Security, published in the Clinical Physiology and Pharmacology. In addition, studies have not consistently shown that vitamin D supplementation tempers the signs and symptoms of active MS or reduces rates of relapse. In a study published in the journal Clinical Science in 2015, researchers from Penn State University found that when older adults and the elderly were exposed to heat, they were less able to increase blood flow than younger adults. Depression Vitamin D. In: Erdman JW, Macdonald IA, Zeisel SH, eds. Clin Pharmacol Ther 2009;85:198-203. Cholecalciferol or vitamin D3 is known to isomerise under various conditions, thereby making its analysis challenging. And that means we need better ways of effectively cooling our bodies, especially when we can't avoid being outside on hot days. WebSeveral typical signs of vitamin D deficiency are: Fatigue and exhaustion Bone pain Muscle weakness, aches, or cramps Mood or behavior changes (such as symptoms of depression) Certain medical conditions or activities can cause this to happen. Observational studies support an association between higher serum 25(OH)D levels and a lower risk of CVD incidence and mortality. causes might be : >Amphetamines or other [, Shea MK, Fielding RA, Dawson-Hughes B. A meta-analysis of prospective studies that evaluated the association between serum 25(OH)D levels and cancer incidence (8 studies) or cancer mortality (16 studies) found that cancer risk decreased by 7% and cancer mortality rates decreased by 2% with each 20 nmol/L (8 ng/mL) increase in serum 25(OH)D levels [89]. AHRQ Publication No. Overall, the risk of CVD events was 10% lower for each 25 nmol/L (10 ng/mL) increase in serum 25(OH)D. Another large observational study that followed 247,574 adults from Denmark for 07 years found that levels of 25(OH)D that were low (about 12.5 nmol/L [5 ng/mL]) and high (about 125 nmol/L [50 ng/mL]) were associated with a greater risk of mortality from CVD, stroke, and acute myocardial infarction [121]. Vitamin D (also referred to as "calciferol") is a fat-soluble vitamin that is naturally present in a few foods, added to others, and available as a dietary supplement. doi: 10.3390/nu10040493. July 01, 2021. In this triple-blind, randomized controlled clinical trial, 93 postmenopausal women were assigned into three groups (two intervention groups and one control group). A study of cohorts that included 5,313 participants who developed lung cancer and 5,313 matched controls found no association between serum 25(OH)D levels and risk of subsequent lung cancer, even when the investigators analyzed the data by sex, age, race and ethnicity, and smoking status [104]. Some people with MS eventually lose the ability to write, speak, or walk. Studies of the effects of vitamin D supplements on hypertension have also had mixed findings. Vitamin D supplementation has no effect on insulin sensitivity or secretion in vitamin D-deficient, overweight or obese adults: A randomized placebo-controlled trial. The combination of high intakes of calcium (about 2,100 mg/day from food and supplements) with moderate amounts of vitamin D (about 19 mcg [765 IU]/day from food and supplements) increased the risk of kidney stones by 17% over 7 years among 36,282 postmenopausal women who were randomly assigned to take 1,000 mg/day calcium and 10 mcg (400 IU)/day vitamin D or a placebo [161]. However, a post hoc analysis showed a 62% lower incidence of diabetes among participants with low baseline serum 25(OH)D levels (less than 30 nmol/L [12 ng/mL]) who took the vitamin D supplement than among those who took the placebo [145,150]. The VITAL trial found no association between vitamin D supplementation and the risk of colorectal adenomas or serrated polyps [103]. The Women's Health Initiative clinical trial randomized 36,282 postmenopausal women to receive 400 IU vitamin D3 plus 1,000 mg calcium daily or a placebo for a mean of 7 years [98]. Studies show that 25(OH)D appears to be approximately five times more potent than the parent vitamin for raising serum 25(OH)D concentrations [17,20,21]. JAMA 2018;319:1630. The significance of vitamin D status in breast cancer: A state of the science review. The results showed no significant differences in rates of progression to type 2 diabetes; in serum glucose, insulin, or hemoglobin A1c levels; or in measures of insulin resistance. However, frequent use of tanning beds, which provide artificial UV radiation, can lead to 25(OH)D levels well above 375500 nmol/L (150200 ng/mL) [158-160]. This damage hinders or blocks messages between the brain and body, leading to clinical features, such as vision loss, motor weakness, spasticity, ataxia, tremor, sensory loss, and cognitive impairment [136,137]. Although UVB exposure can produce vitamin D in infants, the American Academy of Pediatrics (AAP) advises parents to keep infants younger than 6 months out of direct sunlight, dress them in protective clothing and hats, and apply sunscreen on small areas of exposed skin when sun exposure is unavoidable [59]. [, Singh P, Trivedi N. Tanning beds and hypervitaminosis D: A case report.
Weisberg P, Scanlon KS, Li R, Cogswell ME. Older adults are at increased risk of developing vitamin D insufficiency, partly because the skin's ability to synthesize vitamin D declines with age [1,61]. The study included 25,871 men aged 50 years and In fact, 20132016 NHANES data showed that 92% of men, more than 97% of women, and 94% of people aged 1 year and older ingested less than the EAR of 10 mcg (400 IU) of vitamin D from food and beverages [40]. Int J Cancer 2018;142:1189-201. Vitamin D supplementation had no effect on the incidence rate of myocardial infarction, angina, heart failure, arrhythmia, arteriosclerosis, stroke, venous thrombosis, or death from CVD. 
Vitamin D content stays high even when In serum, 25(OH)D has a fairly long circulating half-life of 15 days [1]. WebWalk through the steps of treating and managing a patient who reports muscle symptoms, including cycles of statin discontinuation and rechallenge to identify a tolerated statin and dose. Am J Clin Nutr 2019;110:1043-4. Clinical trials, however, do not support these findings. People who avoid all animal-sourced products can contact dietary supplement manufacturers to ask about their sourcing and processing techniques. Use of vitamin D drops leading to kidney failure in a 54-year-old man. [, Aloia JF, Li-Ng M, Pollack S. Statins and vitamin D. Am J Cardiol 2007;100:1329. N Engl J Med 2019;381:1785-6. Office of Dietary Supplements, National Institutes of Health. US Preventive Services Task Force recommendation statement. [, Durup D, Jorgensen HL, Christensen J, Tjonnland A, Olsen A, Halkjaer J, et al. January 2015. JAMA Oncol 2017;3:351-7. Nutrients 2017, 9, 1308; doi:10.3390/mu9121308. [, Calvo MS, Whiting SJ, Barton CN. Vitamin D supplementation for the prevention of depression and poor physical function in older persons: The D-Vitaal study, a randomized clinical trial. Vitamin D obtained from sun exposure, foods, and supplements is biologically inert and must undergo two hydroxylations in the body for activation. But despite the importance of the sun for vitamin D synthesis, limiting skin exposure to sunlight and UV radiation from tanning beds is prudent [28]. Conclusions about vitamin D and cancer
Effects of vitamin D supplementation on musculoskeletal health: A systematic review, meta-analysis, and trial sequential analysis. Mayo Clin Proc 2013;88:176-83.